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New class of compounds found to block coronavirus reproduction »

mindblowingscience:

A human genetic mechanism hijacked by SARS-CoV-2, the coronavirus behind the COVID-19 pandemic, to help it spread also makes it vulnerable to a new class of drug candidates, a new study finds.

Led by researchers at NYU Grossman School of Medicine, a research team showed that coronavirus reproduction in infected human cells requires chemical changes made by the human protein METTL3 to RNA, a key form of genetic material. Additional human proteins involved in the recognition of modified RNA, YTHDF1 and YTHDF3, were also found to be important to the process.

Published online in Genes and Development on June 24, the study showed for the first time that a molecular inhibitor of METTL3, designed by Storm Therapeutics Ltd and called STM2457, dramatically reduced in cell cultures the replication of both pandemic SARS-CoV-2 and, a less severe, seasonal coronavirus, HCoV-OC43, one cause of the common cold.

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Reblogged 1 year ago from merelygifted (Originally from mindblowingscience)
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  7. dremas393 said: Oh! It would cut your sperm count too… Argh! Here, reading materials on METTL3: en.m.wikipedia.org/wiki…
  8. dremas393 said: I personally studied DNA in high school, have a degree from Purdue University in Infectious diseases and medical sterilization… Makes my statement more correct per say.
  9. dremas393 said: But wouldn’t the supression of METTL3 have some serious consequences to cellular mitosis? From what I just read. It entails protection from UV and signals DNA damage notice. It regulates T cell differentiation. Pretty sure that means ratio of T cells per area… Would assume lack of this would reduce T cell production, UV protection, addressing DNA, mRNA damage. These produce mutated cancer cells from lack of functioning. One who made it can try it out.
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